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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $9.65B
Positions: 93
Period: 2024-09-30
Filed: 2024-11-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$9.65B

Positions

93

New

4

Increased

18

Decreased

2

Sold Out

360

BAKER BROS. ADVISORS LP Q3 2024 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $9.65B across 93 positions in their Q3 2024 SEC 13F filing (period ending 2024-09-30). Top holdings include ONC ($2.37B), INCY ($2.03B), ACAD ($659.46M). The top 10 positions account for 77.9% of the portfolio. This quarter saw 4 new positions, 18 increases, 2 reductions, 360 complete exits. Notable new buys: BCAX ($21.22M), GPCR ($3.75M), WVE ($2.82M). Notable exits: INSM, ATHA, ADAP.

All Holdings

#StockValue↓WeightChange
1
ONCBeiGene, Ltd.
SPONSORED ADR
$2.37B
24.59%
-
2
INCYIncyte Corporation
COM
$2.03B
21.06%
+0.0%
3
ACADACADIA Pharmaceuticals Inc.
COM
$659.46M
6.83%
-
4
SMMTSummit Therapeutics Inc.
COM
$534.90M
5.54%
+5.2%
5
MDGLMadrigal Pharmaceuticals, Inc.
COM
$419.05M
4.34%
-
6
RVMDRevolution Medicines, Inc.
COM
$343.26M
3.56%
-
7
RYTMRhythm Pharmaceuticals, Inc.
COM
$335.21M
3.47%
+0.0%
8
INSMInsmed Incorporated
COM PAR $.01
$322.36M
3.34%
+23.5%
9
KYMRKymera Therapeutics, Inc.
COM
$283.79M
2.94%
+0.0%
10
BCYCBicycle Therapeutics plc
SPONSORED ADS
$212.72M
2.20%
-
11
EWTXEdgewise Therapeutics, Inc.
COM
$155.87M
1.62%
-
12
REPLReplimune Group, Inc.
COM
$121.06M
1.25%
+10.0%
13
ALKSAlkermes plc
SHS
$117.05M
1.21%
-
14
DNLIDenali Therapeutics Inc.
COM
$108.70M
1.13%
-
15
INSMInsmed Incorporated
Note 0.75% 6/1/2028
$98.33M
1.02%
-
16
RAREUltragenyx Pharmaceutical Inc.
COM
$87.55M
0.91%
+7.5%
17
NRIXNurix Therapeutics, Inc.
COM
$87.23M
0.90%
-
18
TRDAEntrada Therapeutics, Inc.
COM
$77.76M
0.81%
-
19
IMTXImmatics N.V.
SHS
$73.52M
0.76%
-
20
ABCLAbCellera Biologics Inc.
COM
$71.57M
0.74%
-
21
KNSAKiniksa Pharmaceuticals International, plc
ORD SHS CL A
$70.43M
0.73%
-
22
IGMSIGM Biosciences, Inc.
COM
$67.69M
0.70%
+0.0%
23
ARGXargenx SE
SPONSORED ADR
$60.66M
0.63%
-
24
STOKStoke Therapeutics, Inc.
COM
$53.69M
0.56%
-
25
IMCRImmunocore Holdings plc
ADS
$47.17M
0.49%
-
26
KODKodiak Sciences Inc.
COM
$45.18M
0.47%
-
27
SERASera Prognostics, Inc.
CLASS A COM
$42.39M
0.44%
-
28
CRSPCRISPR Therapeutics AG
NAMEN AKT
$39.61M
0.41%
+743.1%
29
XENEXenon Pharmaceuticals Inc.
COM
$39.12M
0.41%
-
30
IMVTImmunovant, Inc.
COM
$34.94M
0.36%
+163.7%
31
CERSCerus Corporation
COM
$33.89M
0.35%
-
32
IDYAIDEAYA Biosciences, Inc.
COM
$33.65M
0.35%
-
33
ROIVRoivant Sciences Ltd.
SHS
$32.30M
0.33%
-
34
AKROAkero Therapeutics, Inc.
COM
$31.48M
0.33%
-
35
KRYSKrystal Biotech, Inc.
COM
$30.93M
0.32%
-
36
CELCCelcuity Inc.
COM
$27.96M
0.29%
-
37
GLUEMonte Rosa Therapeutics, Inc.
COM
$26.06M
0.27%
-
38
DYNDyne Therapeutics, Inc.
COM
$24.14M
0.25%
-
39
BMEABiomea Fusion, Inc.
COM
$21.30M
0.22%
-
40
BCAXBicara Therapeutics Inc.
COM
$21.22M
0.22%
New
41
PRLDPrelude Therapeutics Inc.
COM
$20.96M
0.22%
-
42
CNTACentessa Pharmaceuticals plc
SPONSORED ADS
$19.62M
0.20%
+123.4%
43
NGNENeurogene Inc.
COM
$19.13M
0.20%
-
44
PRAXPraxis Precision Medicines, Inc.
COM
$18.59M
0.19%
+145.6%
45
ALMSAlumis Inc.
COM
$16.69M
0.17%
-
46
MRUSMerus N.V.
COM
$14.99M
0.16%
-
47
TCRXTScan Therapeutics, Inc.
COM
$13.87M
0.14%
-
48
NMRANeumora Therapeutics, Inc.
COM
$13.67M
0.14%
-
49
XNCRXencor, Inc.
COM
$13.48M
0.14%
+22.9%
50
TSVT2seventy bio, Inc.
COMMON STOCK
$11.79M
0.12%
-
Showing 1-50 of 93

Position Changes

StockValueShares
BCAXBicara Therapeutics Inc.
$21.22M833,333
GPCRStructure Therapeutics Inc.
$3.75M85,500
WVEWave Life Sciences Ltd.
$2.82M344,063
ALGSAligos Therapeutics, Inc.
$719.26K83,055