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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $23.07B
Positions: 126
Period: 2021-03-31
Filed: 2021-05-17
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$23.07B

Positions

126

New

12

Increased

23

Decreased

15

Sold Out

225

BAKER BROS. ADVISORS LP Q1 2021 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $23.07B across 126 positions in their Q1 2021 SEC 13F filing (period ending 2021-03-31). Top holdings include SE ($6.56B), ONC ($4.06B), INCY ($2.60B). The top 10 positions account for 80.5% of the portfolio. This quarter saw 12 new positions, 23 increases, 15 reductions, 225 complete exits. Notable new buys: IMCR ($107.31M), TIL ($97.65M), MEDG ($97.34M). Notable exits: VXRT, OVID, THCH.

All Holdings

#StockValue↓WeightChange
1
SESeagen Inc.
COM
$6.56B
28.46%
+0.0%
2
ONCBeiGene, Ltd.
SPONSORED ADR
$4.06B
17.61%
-
3
INCYIncyte Corporation
COM
$2.60B
11.28%
+0.0%
4
KODKodiak Sciences Inc.
COM
$1.57B
6.82%
-
5
ACADACADIA Pharmaceuticals Inc.
COM
$1.08B
4.69%
+0.0%
6
Alexion Pharmaceuticals, Inc.
COM
$610.62M
2.65%
-54.4%
7
Invitae Corporation
COM
$601.78M
2.61%
+0.6%
8
BMRNBioMarin Pharmaceutical Inc.
COM
$573.07M
2.48%
-
9
ASNDAscendis Pharma A/S
SPONSORED ADR
$456.27M
1.98%
-
10
PRLDPrelude Therapeutics Incorporated
COM
$438.67M
1.90%
+0.1%
11
ABCLAbCellera Biologics Inc.
COM
$354.89M
1.54%
-
12
ARGXargenx SE
SPONSORED ADR
$308.31M
1.34%
+9.8%
13
IGMSIGM Biosciences, Inc.
COM
$242.04M
1.05%
+0.4%
14
ATIMirati Therapeutics, Inc.
COM
$241.50M
1.05%
-
15
MDGLMadrigal Pharmaceuticals, Inc.
COM
$175.36M
0.76%
-
16
AMRNAmarin Corporation plc
SPONSORED ADR
$164.28M
0.71%
-5.5%
17
THCHGlobal Blood Therapeutics, Inc.
COM
$131.11M
0.57%
+249.6%
18
BCRXBioCryst Pharmaceuticals, Inc.
COM
$129.27M
0.56%
+0.1%
19
IMCRImmunocore Holdings plc
ADS
$107.31M
0.47%
New
20
PACBPacific Biosciences of California, Inc.
COM
$106.66M
0.46%
-
21
TILInstil Bio, Inc.
COM
$97.65M
0.42%
New
22
MEDGTalis Biomedical Corporation
COM
$97.34M
0.42%
New
23
HRTXHeron Therapeutics, Inc.
COM
$97.17M
0.42%
-
24
CERSCerus Corporation
COM
$82.42M
0.36%
-
25
ALLKAllakos Inc.
COM
$80.70M
0.35%
-1.6%
26
DBV Technologies S.A.
SPONSORED ADR
$77.89M
0.34%
-
27
NRIXNurix Therapeutics, Inc.
COM
$76.30M
0.33%
+37.2%
28
KYMRKymera Therapeutics, Inc.
COM
$76.14M
0.33%
-
29
RYTMRhythm Pharmaceuticals, Inc.
COM
$74.02M
0.32%
+50.3%
30
INSMInsmed Incorporated
COM PAR $.01
$73.43M
0.32%
-
31
APLSApellis Pharmaceuticals, Inc.
COM
$71.83M
0.31%
+86.7%
32
NBIXNeurocrine Biosciences, Inc.
COM
$65.84M
0.29%
-
33
KRYSKrystal Biotech, Inc.
COM
$58.58M
0.25%
+8.8%
34
THCHForma Therapeutics Holdings, Inc.
SHS
$56.74M
0.25%
-
35
THCHHorizon Therapeutics Public Ltd Co
SHS
$55.14M
0.24%
-
36
Atreca, Inc.
CL A COM
$54.16M
0.23%
-
37
ZYMEZymeworks Inc.
COM
$53.95M
0.23%
-
38
ADAPAdaptimmune Therapeutics plc
SPONSORED ADR
$52.20M
0.23%
-
39
KNSAKiniksa Pharmaceuticals, Ltd.
COM CL A
$51.82M
0.22%
-
40
RAREUltragenyx Pharmaceutical Inc.
COM
$50.60M
0.22%
-
41
THCHNeoleukin Therapeutics, Inc.
COM
$47.05M
0.20%
-
42
IMTXImmatics N.V.
SHS
$44.76M
0.19%
+121.2%
43
DSGNDesign Therapeutics, Inc.
COM
$42.95M
0.19%
New
44
THCHAchilles Therapeutics plc
SPONSORED ADS
$42.89M
0.19%
New
45
MRUSMerus N.V.
COM
$42.56M
0.18%
-
46
VSTMVerastem, Inc.
COM
$42.04M
0.18%
+67.8%
47
BCABBioAtla, Inc.
COM
$41.94M
0.18%
-
48
ALTAltimmune, Inc.
COM
$38.98M
0.17%
+46.4%
49
FLGTFulgent Genetics, Inc.
COM
$38.75M
0.17%
-19.1%
50
PTGXProtagonist Therapeutics, Inc.
COM
$37.20M
0.16%
-
Showing 1-50 of 126

Position Changes

StockValueShares
IMCRImmunocore Holdings plc
$107.31M2,520,730
TILInstil Bio, Inc.
$97.65M3,893,700
MEDGTalis Biomedical Corporation
$97.34M7,574,835
DSGNDesign Therapeutics, Inc.
$42.95M1,436,636
THCHAchilles Therapeutics plc
$42.89M2,591,366
Otonomy, Inc.
$18.41M7,220,074
EWTXEdgewise Therapeutics, Inc.
$16.25M500,000
SRPTSarepta Therapeutics, Inc.
$11.97M9,174,000
RVMDRevolution Medicines, Inc.
$10.20M222,222
NexImmune, Inc.
$5.61M294,117
TVTXTravere Therapeutics, Inc.
$4.67M186,915
SRPTSarepta Therapeutics, Inc.
$4.38M58,700