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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $15.27B
Positions: 115
Period: 2022-09-30
Filed: 2022-11-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$15.27B

Positions

115

New

11

Increased

8

Decreased

17

Sold Out

276

BAKER BROS. ADVISORS LP Q3 2022 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $15.27B across 115 positions in their Q3 2022 SEC 13F filing (period ending 2022-09-30). Top holdings include SE ($6.42B), INCY ($2.41B), ONC ($1.57B). The top 10 positions account for 84.7% of the portfolio. This quarter saw 11 new positions, 8 increases, 17 reductions, 276 complete exits. Notable new buys: CinCor Pharma, Inc. ($26.49M), BCYC ($19.63M), VERU ($18.54M). Notable exits: SRPT, EVFM, CNTA.

All Holdings

#StockValue↓WeightChange
1
SESeagen Inc.
COM
$6.42B
42.04%
-
2
INCYIncyte Corporation
COM
$2.41B
15.78%
+0.0%
3
ONCBeiGene, Ltd.
SPONSORED ADR
$1.57B
10.30%
-
4
ACADACADIA Pharmaceuticals Inc.
COM
$685.87M
4.49%
-
5
BMRNBioMarin Pharmaceutical Inc.
COM
$645.99M
4.23%
-
6
ASNDAscendis Pharma A/S
SPONSORED ADR
$501.08M
3.28%
-
7
THCHGlobal Blood Therapeutics, Inc.
COM
$254.18M
1.66%
-
8
BCRXBioCryst Pharmaceuticals, Inc.
COM
$160.16M
1.05%
-
9
RYTMRhythm Pharmaceuticals, Inc.
COM
$148.54M
0.97%
+47.0%
10
KODKodiak Sciences Inc.
COM
$133.98M
0.88%
-
11
IMCRImmunocore Holdings plc
ADS
$118.32M
0.77%
+0.0%
12
ABCLAbCellera Biologics Inc.
COM
$103.35M
0.68%
-
13
ARGXargenx SE
SPONSORED ADR
$98.91M
0.65%
-75.0%
14
ATIMirati Therapeutics, Inc.
COM
$98.46M
0.64%
-
15
MDGLMadrigal Pharmaceuticals, Inc.
COM
$97.43M
0.64%
-
16
ChemoCentryx, Inc.
COM
$92.61M
0.61%
-
17
TVTXTravere Therapeutics, Inc.
COM
$81.31M
0.53%
-
18
AKROAkero Therapeutics, Inc.
COM
$80.64M
0.53%
+1900.7%
19
TRDAEntrada Therapeutics, Inc.
COM
$76.69M
0.50%
-
20
IGMSIGM Biosciences, Inc.
COM
$71.77M
0.47%
-
21
REPLReplimune Group, Inc.
COM
$67.25M
0.44%
+8.4%
22
PRLDPrelude Therapeutics Inc.
COM
$66.92M
0.44%
-
23
KYMRKymera Therapeutics, Inc.
COM
$62.69M
0.41%
-
24
THCHHorizon Therapeutics Public Ltd Co
SHS
$60.02M
0.39%
-15.6%
25
CERSCerus Corporation
COM
$57.84M
0.38%
-
26
NRIXNurix Therapeutics, Inc.
COM
$50.58M
0.33%
-
27
THCHChinook Therapeutics, Inc.
COM
$49.82M
0.33%
-
28
VERVVerve Therapeutics, Inc.
COM
$48.66M
0.32%
-
29
IMTXImmatics N.V.
SHS
$44.24M
0.29%
-
30
THCHForma Therapeutics Holdings, Inc.
SHS
$37.64M
0.25%
-6.8%
31
INSMInsmed Incorporated
Note 0.75% 6/1/2028
$36.30M
0.24%
-
32
KNSAKiniksa Pharmaceuticals, Ltd.
COM CL A
$35.95M
0.24%
-
33
HRTXHeron Therapeutics, Inc.
COM
$34.32M
0.22%
-
34
THCHAerovate Therapeutics, Inc.
COM
$32.82M
0.21%
-4.4%
35
TSVT2seventy bio, Inc.
COM
$30.01M
0.20%
-
36
KRYSKrystal Biotech, Inc.
COM
$29.43M
0.19%
-47.7%
37
XENEXenon Pharmaceuticals Inc.
COM
$27.13M
0.18%
-
38
CinCor Pharma, Inc.
COM
$26.49M
0.17%
New
39
DBV Technologies S.A.
SPONSORED ADR
$25.87M
0.17%
-
40
IDYAIDEAYA Biosciences, Inc.
COM
$24.89M
0.16%
+0.0%
41
DSGNDesign Therapeutics, Inc.
COM
$24.02M
0.16%
-
42
VSTMVerastem, Inc.
COM
$22.94M
0.15%
-
43
ALTAltimmune, Inc.
COM
$22.60M
0.15%
-14.7%
44
Invitae Corporation
COM
$20.67M
0.14%
-14.9%
45
BMEABiomea Fusion, Inc.
COM
$20.58M
0.13%
-
46
BCYCBicycle Therapeutics plc
SPONSORED ADS
$19.63M
0.13%
New
47
RAREUltragenyx Pharmaceutical Inc.
COM
$19.50M
0.13%
-
48
TILInstil Bio, Inc.
COM
$18.85M
0.12%
-
49
VERUVeru Inc.
COM
$18.54M
0.12%
New
50
RLMDRelmada Therapeutics, Inc.
COM
$18.33M
0.12%
-
Showing 1-50 of 115

Position Changes

StockValueShares
CinCor Pharma, Inc.
$26.49M807,212
BCYCBicycle Therapeutics plc
$19.63M843,814
VERUVeru Inc.
$18.54M1,609,579
WHWKAadi Bioscience, Inc.
$13.99M989,928
GTLLPOINT Biopharma Global Inc.
$9.04M1,169,103
KRONKronos Bio, Inc.
$5.16M1,539,616
FATEFate Therapeutics, Inc.
$4.83M215,695
STOKStoke Therapeutics, Inc.
$4.74M369,327
Eiger BioPharmaceuticals, Inc.
$4.07M539,851
PMVPPMV Pharmaceuticals, Inc.
$3.83M322,024
IPSCCentury Therapeutics, Inc.
$3.67M370,587