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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $12.33B
Positions: 121
Period: 2017-09-30
Filed: 2017-11-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$12.33B

Positions

121

New

7

Increased

27

Decreased

11

Sold Out

103

BAKER BROS. ADVISORS LP Q3 2017 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $12.33B across 121 positions in their Q3 2017 SEC 13F filing (period ending 2017-09-30). Top holdings include INCY ($4.00B), SE ($2.49B), Alexion Pharmaceuticals, Inc. ($1.20B). The top 10 positions account for 85.9% of the portfolio. This quarter saw 7 new positions, 27 increases, 11 reductions, 103 complete exits. Notable new buys: BMRN ($15.19M), TTEK ($6.39M), VYGR ($4.88M). Notable exits: PTNT, Alder BioPharmaceuticals, Inc., NODK.

All Holdings

#StockValue↓WeightChange
1
INCYIncyte Corporation
COM
$4.00B
32.41%
+0.3%
2
SESeattle Genetics, Inc.
COM
$2.49B
20.18%
-
3
Alexion Pharmaceuticals, Inc.
COM
$1.20B
9.73%
-
4
ACADACADIA Pharmaceuticals Inc.
COM
$972.63M
7.89%
-
5
BMRNBioMarin Pharmaceutical Inc.
COM
$549.64M
4.46%
-
6
THCHGenomic Health, Inc.
COM
$442.21M
3.59%
+0.0%
7
ONCBeiGene, Ltd.
SPONSORED ADR
$403.33M
3.27%
+6.1%
8
DBV Technologies S.A.
SPONSORED ADR
$233.83M
1.90%
-
9
Aquinox Pharmaceuticals, Inc.
COM
$155.16M
1.26%
-
10
PPLAdvanced Accelerator Applications S.A.
SPONSORED ADS
$151.69M
1.23%
+1.0%
11
PARSpark Therapeutics, Inc.
COM
$123.41M
1.00%
+5.0%
12
ASNDAscendis Pharma A/S
SPONSORED ADR
$85.14M
0.69%
+34.1%
13
AMRNAmarin Corporation plc
SPONSORED ADR NEW
$79.34M
0.64%
-
14
AveXis, Inc.
COM
$74.97M
0.61%
+24.0%
15
BCRXBioCryst Pharmaceuticals, Inc.
COM
$73.35M
0.59%
+19.5%
16
Invitae Corporation
COM
$68.29M
0.55%
-
17
ARRYArray BioPharma Inc.
COM
$64.13M
0.52%
+228.7%
18
Achaogen, Inc.
COM
$62.00M
0.50%
-19.1%
19
Bellicum Pharmaceuticals, Inc.
COM
$58.12M
0.47%
-
20
EXELExelixis, Inc.
COM
$50.45M
0.41%
-
21
HRTXHeron Therapeutics, Inc.
COM
$45.03M
0.37%
+0.2%
22
NVAXNovavax, Inc.
NOTE 3.75% 2/1/2023
$39.54M
0.32%
-18.4%
23
NBIXNeurocrine Biosciences, Inc.
COM
$37.79M
0.31%
-
24
BLUEbluebird bio, Inc.
COM
$33.16M
0.27%
-19.9%
25
SGMOSangamo Therapeutics, Inc.
COM
$31.70M
0.26%
-48.6%
26
THCHAcorda Therapeutics, Inc.
NOTE 1.75% 6/15/2021
$31.57M
0.26%
-
27
ABEOAbeona Therapeutics Inc.
COM
$28.72M
0.23%
-
28
HALOHalozyme Therapeutics, Inc.
COM
$27.47M
0.22%
-
29
CERSCerus Corporation
COM
$26.60M
0.22%
-4.8%
30
ATIMirati Therapeutics, Inc.
COM
$26.55M
0.22%
-
31
GLPGGalapagos NV
SPONSORED ADR
$26.44M
0.21%
-
32
NTLAIntellia Therapeutics, Inc.
COM
$26.39M
0.21%
-
33
SAGESage Therapeutics, Inc.
COM
$25.26M
0.20%
+94.6%
34
THCHCymaBay Therapeutics, Inc.
COM
$24.11M
0.20%
+131.6%
35
PRGProgenics Pharmaceuticals, Inc.
COM
$23.19M
0.19%
-
36
MRUSMerus N.V.
COM
$23.05M
0.19%
-
37
Idera Pharmaceuticals, Inc.
COM NEW
$22.98M
0.19%
+0.1%
38
NeuroDerm Ltd.
ORD SHS
$22.24M
0.18%
-
39
INSMInsmed Incorporated
COM PAR $.01
$21.85M
0.18%
+75.0%
40
ImmunoGen, Inc.
COM
$20.57M
0.17%
-10.8%
41
XNCRXencor, Inc.
COM
$19.99M
0.16%
-
42
THCHAimmune Therapeutics, Inc.
COM
$16.71M
0.14%
-
43
Ignyta, Inc.
COM
$16.05M
0.13%
+45.0%
44
MyoKardia, Inc.
COM
$15.22M
0.12%
+255.3%
45
BMRNBioMarin Pharmaceutical Inc.
NOTE 0.599% 8/1/2024 ADDED
$15.19M
0.12%
New
46
AERIEURAerie Pharmaceuticals, Inc.
COM
$14.55M
0.12%
-
47
Foamix Pharmaceuticals Ltd.
SHS
$13.69M
0.11%
-
48
BMRNBioMarin Pharmaceutical Inc.
NOTE 0.75% 10/15/2018
$13.63M
0.11%
-
49
CPRXCatalyst Pharmaceuticals, Inc.
COM
$12.86M
0.10%
-
50
THCHAcorda Therapeutics, Inc.
COM
$12.29M
0.10%
+0.0%
Showing 1-50 of 121

Position Changes

StockValueShares
BMRNBioMarin Pharmaceutical Inc.
$15.19M15,000,000
TTEKTetraphase Pharmaceuticals, Inc.
$6.39M935,000
VYGRVoyager Therapeutics, Inc.
$4.88M237,014
Clementia Pharmaceuticals Inc.
$4.22M250,000
KRYSKrystal Biotech, Inc.
$1.99M200,000
Molecular Templates, Inc.
$505.00K72,412
TTOOT2 Biosystems, Inc.
$420.00K100,000