SmartMoneyDB

BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $7.83B
Positions: 95
Period: 2024-06-30
Filed: 2024-08-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$7.83B

Positions

95

New

9

Increased

24

Decreased

11

Sold Out

354

BAKER BROS. ADVISORS LP Q2 2024 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $7.83B across 95 positions in their Q2 2024 SEC 13F filing (period ending 2024-06-30). Top holdings include INCY ($1.86B), ONC ($1.51B), ACAD ($696.77M). The top 10 positions account for 76.3% of the portfolio. This quarter saw 9 new positions, 24 increases, 11 reductions, 354 complete exits. Notable new buys: INSM ($56.19M), KNSA ($52.62M), ALMS ($20.78M). Notable exits: DBV Technologies S.A., HOOK, KNSA.

All Holdings

#StockValue↓WeightChange
1
INCYIncyte Corporation
COM
$1.86B
23.81%
-15.0%
2
ONCBeiGene, Ltd.
SPONSORED ADR
$1.51B
19.27%
-
3
ACADACADIA Pharmaceuticals Inc.
COM
$696.77M
8.90%
+0.0%
4
MDGLMadrigal Pharmaceuticals, Inc.
COM
$553.20M
7.07%
+0.2%
5
RVMDRevolution Medicines, Inc.
COM
$293.76M
3.75%
+0.3%
6
RYTMRhythm Pharmaceuticals, Inc.
COM
$262.72M
3.36%
-
7
INSMInsmed Incorporated
COM PAR $.01
$239.59M
3.06%
+942.6%
8
BCYCBicycle Therapeutics plc
SPONSORED ADS
$190.26M
2.43%
+90.2%
9
SMMTSummit Therapeutics Inc.
COM
$181.13M
2.31%
+0.0%
10
KYMRKymera Therapeutics, Inc.
COM
$178.98M
2.29%
-
11
EWTXEdgewise Therapeutics, Inc.
COM
$105.18M
1.34%
-
12
ALKSAlkermes plc
SHS
$100.78M
1.29%
+0.0%
13
INSMInsmed Incorporated
Note 0.75% 6/1/2028
$90.41M
1.16%
+0.0%
14
REPLReplimune Group, Inc.
COM
$90.41M
1.16%
+5.2%
15
DNLIDenali Therapeutics Inc.
COM
$86.65M
1.11%
-
16
ABCLAbCellera Biologics Inc.
COM
$81.48M
1.04%
-
17
NRIXNurix Therapeutics, Inc.
COM
$81.02M
1.04%
-
18
IMTXImmatics N.V.
SHS
$74.87M
0.96%
-
19
TRDAEntrada Therapeutics, Inc.
COM
$69.34M
0.89%
-
20
RAREUltragenyx Pharmaceutical Inc.
COM
$60.28M
0.77%
-
21
STOKStoke Therapeutics, Inc.
COM
$59.02M
0.75%
+29.7%
22
INSMInsmed Incorporated
Note 1.75% 1/15/2025
$56.19M
0.72%
New
23
KNSAKiniksa Pharmaceuticals International, plc
ORD SHS CL A
$52.62M
0.67%
New
24
IMCRImmunocore Holdings plc
ADS
$51.35M
0.66%
-
25
ARGXargenx SE
SPONSORED ADR
$48.12M
0.61%
-26.0%
26
KODKodiak Sciences Inc.
COM
$40.68M
0.52%
-
27
XENEXenon Pharmaceuticals Inc.
COM
$38.74M
0.50%
-
28
PRLDPrelude Therapeutics Inc.
COM
$38.57M
0.49%
-
29
IDYAIDEAYA Biosciences, Inc.
COM
$37.29M
0.48%
-
30
CERSCerus Corporation
COM
$34.28M
0.44%
-
31
SERASera Prognostics, Inc.
CLASS A COM
$32.17M
0.41%
-
32
KRYSKrystal Biotech, Inc.
COM
$31.21M
0.40%
-
33
CELCCelcuity Inc.
COM
$30.71M
0.39%
+20.8%
34
ROIVRoivant Sciences Ltd.
SHS
$29.58M
0.38%
-62.3%
35
IGMSIGM Biosciences, Inc.
COM
$28.10M
0.36%
+0.0%
36
THCHCerevel Therapeutics Holdings, Inc.
COM
$27.95M
0.36%
-57.3%
37
AKROAkero Therapeutics, Inc.
COM
$25.74M
0.33%
-59.6%
38
DYNDyne Therapeutics, Inc.
COM
$23.72M
0.30%
+135.8%
39
ALMSAlumis Inc.
COM
$20.78M
0.27%
New
40
GLUEMonte Rosa Therapeutics, Inc.
COM
$18.39M
0.23%
-
41
MRUSMerus N.V.
COM
$17.75M
0.23%
+0.0%
42
NGNENeurogene Inc.
COM
$16.59M
0.21%
-
43
TCRXTScan Therapeutics, Inc.
COM
$16.29M
0.21%
-
44
SANASana Biotechnology, Inc.
COM
$13.00M
0.17%
-
45
IMVTImmunovant, Inc.
COM
$12.27M
0.16%
+9.3%
46
XNCRXencor, Inc.
COM
$10.33M
0.13%
-
47
NMRANeumora Therapeutics, Inc.
COM
$10.17M
0.13%
+63.2%
48
FATEFate Therapeutics, Inc.
COM
$9.83M
0.13%
+64.9%
49
TSVT2seventy bio, Inc.
COMMON STOCK
$9.62M
0.12%
-
50
BMEABiomea Fusion, Inc.
COM
$9.49M
0.12%
-
Showing 1-50 of 95

Position Changes

StockValueShares
INSMInsmed Incorporated
$56.19M32,887,000
KNSAKiniksa Pharmaceuticals International, plc
$52.62M2,818,323
ALMSAlumis Inc.
$20.78M1,562,500
DBVTDBV Technologies S.A.
$5.85M7,307,131
CTNMContineum Therapeutics, Inc.
$5.50M312,500
CRSPCRISPR Therapeutics AG
$5.40M100,000
HOOKHOOKIPA Pharma Inc.
$4.81M8,128,151
SKYESkye Bioscience, Inc.
$4.00M500,000
ARCTArcturus Therapeutics Holdings Inc.
$3.68M151,329