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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $17.35B
Positions: 101
Period: 2023-09-30
Filed: 2023-11-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$17.35B

Positions

101

New

8

Increased

17

Decreased

12

Sold Out

323

BAKER BROS. ADVISORS LP Q3 2023 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $17.35B across 101 positions in their Q3 2023 SEC 13F filing (period ending 2023-09-30). Top holdings include SE ($9.45B), ONC ($2.10B), INCY ($2.09B). The top 10 positions account for 90.2% of the portfolio. This quarter saw 8 new positions, 17 increases, 12 reductions, 323 complete exits. Notable new buys: IMVT ($16.32M), ARVN ($8.12M), TSHA ($7.92M). Notable exits: THCH, MREO, THCH.

All Holdings

#StockValue↓WeightChange
1
SESeagen Inc.
COM
$9.45B
54.48%
-
2
ONCBeiGene, Ltd.
SPONSORED ADR
$2.10B
12.10%
-
3
INCYIncyte Corporation
COM
$2.09B
12.05%
+0.0%
4
ACADACADIA Pharmaceuticals Inc.
COM
$893.30M
5.15%
-
5
BMRNBioMarin Pharmaceutical Inc.
COM
$337.13M
1.94%
-
6
MDGLMadrigal Pharmaceuticals, Inc.
COM
$225.65M
1.30%
-
7
RYTMRhythm Pharmaceuticals, Inc.
COM
$153.65M
0.89%
+3.1%
8
ROIVRoivant Sciences Ltd.
SHS
$138.73M
0.80%
+26.0%
9
IMCRImmunocore Holdings plc
ADS
$130.83M
0.75%
-
10
ATIInvitae Corporation
Note 1.5% 4/1/2028
$130.37M
0.75%
-
11
AKROAkero Therapeutics, Inc.
COM
$119.79M
0.69%
-
12
ABCLAbCellera Biologics Inc.
COM
$95.51M
0.55%
+26.2%
13
BCRXBioCryst Pharmaceuticals, Inc.
COM
$89.99M
0.52%
-
14
REPLReplimune Group, Inc.
COM
$78.33M
0.45%
-
15
TRDAEntrada Therapeutics, Inc.
COM
$76.88M
0.44%
-
16
RVMDRevolution Medicines, Inc.
COM
$74.50M
0.43%
-
17
ARGXargenx SE
SPONSORED ADR
$74.34M
0.43%
-46.0%
18
SWTXSpringWorks Therapeutics, Inc.
COM
$69.36M
0.40%
-
19
KYMRKymera Therapeutics, Inc.
COM
$66.03M
0.38%
+8.6%
20
IMTXImmatics N.V.
SHS
$65.32M
0.38%
-
21
ATIMirati Therapeutics, Inc.
COM
$61.41M
0.35%
-
22
KNSAKiniksa Pharmaceuticals, Ltd.
COM CL A
$48.80M
0.28%
-
23
RAREUltragenyx Pharmaceutical Inc.
COM
$48.72M
0.28%
+74.5%
24
DNLIDenali Therapeutics Inc.
COM
$47.28M
0.27%
+57.5%
25
PRLDPrelude Therapeutics Inc.
COM
$31.28M
0.18%
-
26
KODKodiak Sciences Inc.
COM
$31.16M
0.18%
-
27
NRIXNurix Therapeutics, Inc.
COM
$30.51M
0.18%
-
28
BMEABiomea Fusion, Inc.
COM
$29.02M
0.17%
-
29
IDYAIDEAYA Biosciences, Inc.
COM
$28.66M
0.17%
-
30
CERSCerus Corporation
COM
$27.93M
0.16%
+7.3%
31
THCHAerovate Therapeutics, Inc.
COM
$26.64M
0.15%
-
32
IGMSIGM Biosciences, Inc.
COM
$26.37M
0.15%
+0.0%
33
XENEXenon Pharmaceuticals Inc.
COM
$25.68M
0.15%
-
34
CABACabaletta Bio, Inc.
COM
$24.26M
0.14%
-
35
GLUEMonte Rosa Therapeutics, Inc.
COM
$23.55M
0.14%
+62.6%
36
DBV Technologies S.A.
SPONSORED ADR
$19.88M
0.11%
-
37
KRYSKrystal Biotech, Inc.
COM
$19.71M
0.11%
-
38
VERVVerve Therapeutics, Inc.
COM
$18.78M
0.11%
-
39
BCYCBicycle Therapeutics plc
SPONSORED ADS
$16.95M
0.10%
-
40
IMVTImmunovant, Inc.
COM
$16.32M
0.09%
New
41
COGTCogent Biosciences, Inc.
COM
$12.61M
0.07%
+32.0%
42
DAWNDay One Biopharmaceuticals, Inc.
COM
$12.27M
0.07%
-
43
PRMEPrime Medicine, Inc.
COM
$9.81M
0.06%
-
44
TSVT2seventy bio, Inc.
COM
$9.79M
0.06%
-
45
RLAYRelay Therapeutics, Inc.
COM
$9.76M
0.06%
-
46
PACBPacific Biosciences of California, Inc.
COM
$9.42M
0.05%
-
47
INSMInsmed Incorporated
COM PAR $.01
$8.66M
0.05%
-
48
ADAPAdaptimmune Therapeutics plc
SPONSORED ADR
$8.56M
0.05%
-
49
TNGXTango Therapeutics, Inc.
COM
$8.45M
0.05%
-
50
HRTXHeron Therapeutics, Inc.
COM
$8.38M
0.05%
-
Showing 1-50 of 101

Position Changes

StockValueShares
IMVTImmunovant, Inc.
$16.32M425,009
ARVNArvinas, Inc.
$8.12M413,481
TSHATaysha Gene Therapies, Inc.
$7.92M2,504,756
SGMTSagimet Biosciences Inc.
$7.18M815,359
ATIInvitae Corporation
$6.21M9,274,000
PHILMorphic Holding, Inc.
$4.94M215,800
CELCCelcuity Inc.
$4.89M535,478
THCHNeoleukin Therapeutics, Inc.
$4.82M1,221,414