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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $22.67B
Positions: 114
Period: 2020-06-30
Filed: 2020-08-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$22.67B

Positions

114

New

14

Increased

21

Decreased

17

Sold Out

200

BAKER BROS. ADVISORS LP Q2 2020 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $22.67B across 114 positions in their Q2 2020 SEC 13F filing (period ending 2020-06-30). Top holdings include SE ($8.03B), INCY ($3.33B), ONC ($2.22B). The top 10 positions account for 85.2% of the portfolio. This quarter saw 14 new positions, 21 increases, 17 reductions, 200 complete exits. Notable new buys: THCH ($92.98M), ADCT ($78.99M), ALT ($22.57M). Notable exits: MIRA, BioDelivery Sciences International, Inc., THCH.

All Holdings

#StockValue↓WeightChange
1
SESeattle Genetics, Inc.
COM
$8.03B
35.43%
-5.6%
2
INCYIncyte Corporation
COM
$3.33B
14.67%
+0.1%
3
ONCBeiGene, Ltd.
SPONSORED ADR
$2.22B
9.79%
-
4
ACADACADIA Pharmaceuticals Inc.
COM
$2.03B
8.96%
-
5
Alexion Pharmaceuticals, Inc.
COM
$983.31M
4.34%
-
6
BMRNBioMarin Pharmaceutical Inc.
COM
$936.06M
4.13%
-
7
KODKodiak Sciences Inc.
COM
$626.41M
2.76%
-
8
ASNDAscendis Pharma A/S
SPONSORED ADR
$501.42M
2.21%
-
9
Invitae Corporation
COM
$358.97M
1.58%
+30.2%
10
MyoKardia, Inc.
COM
$305.73M
1.35%
+78.3%
11
AMRNAmarin Corporation plc
SPONSORED ADR
$238.72M
1.05%
-
12
ARGXargenx SE
SPONSORED ADR
$229.63M
1.01%
-
13
IGMSIGM Biosciences, Inc.
COM
$229.53M
1.01%
+0.0%
14
MDGLMadrigal Pharmaceuticals, Inc.
COM
$169.79M
0.75%
-
15
ATIMirati Therapeutics, Inc.
COM
$160.96M
0.71%
-
16
EXASExact Sciences Corporation
COM
$160.50M
0.71%
-
17
NBIXNeurocrine Biosciences, Inc.
COM
$110.65M
0.49%
-26.9%
18
Principia Biopharma Inc.
COM
$94.52M
0.42%
-19.2%
19
THCHForma Therapeutics Holdings, Inc.
SHS
$92.98M
0.41%
New
20
CERSCerus Corporation
COM
$90.51M
0.40%
-
21
HRTXHeron Therapeutics, Inc.
COM
$88.53M
0.39%
-
22
INSMInsmed Incorporated
COM PAR $.01
$83.32M
0.37%
-
23
AXSMAxsome Therapeutics, Inc.
COM
$83.08M
0.37%
+13.5%
24
ADCTADC Therapeutics SA
SHS
$78.99M
0.35%
New
25
Atreca, Inc.
CL A COM
$75.18M
0.33%
-
26
KNSAKiniksa Pharmaceuticals, Ltd.
COM CL A
$71.33M
0.31%
-
27
ADAPAdaptimmune Therapeutics plc
SPONSORED ADR
$66.82M
0.29%
+80.9%
28
BCRXBioCryst Pharmaceuticals, Inc.
COM
$65.60M
0.29%
+25.8%
29
DBV Technologies S.A.
SPONSORED ADR
$64.16M
0.28%
-
30
ZYMEZymeworks Inc.
COM
$61.63M
0.27%
-
31
RYTMRhythm Pharmaceuticals, Inc.
COM
$60.21M
0.27%
-0.3%
32
THCHNeoleukin Therapeutics, Inc.
COM
$56.40M
0.25%
-
33
ChemoCentryx, Inc.
COM
$54.39M
0.24%
+10.0%
34
ALLKAllakos Inc.
COM
$52.85M
0.23%
-
35
NBIXNeurocrine Biosciences, Inc.
NOTE 2.25% 5/15/2024
$51.14M
0.23%
-
36
THCHAeglea BioTherapeutics, Inc.
COM
$40.51M
0.18%
+155.6%
37
ASMBAssembly Biosciences, Inc.
COM
$35.95M
0.16%
-
38
KRYSKrystal Biotech, Inc.
COM
$33.87M
0.15%
-13.6%
39
PTGXProtagonist Therapeutics, Inc.
COM
$33.76M
0.15%
+13.8%
40
MRUSMerus N.V.
COM
$32.78M
0.14%
-
41
APLSApellis Pharmaceuticals, Inc.
COM
$29.28M
0.13%
-
42
AUPHAurinia Pharmaceuticals Inc.
COM
$27.66M
0.12%
-
43
ALKSAlkermes plc
SHS
$24.15M
0.11%
-
44
GW Pharmaceuticals plc
ADS
$22.71M
0.10%
-50.1%
45
ALTAltimmune, Inc.
COM
$22.57M
0.10%
New
46
APTVAdaptive Biotechnologies Corporation
COM
$22.43M
0.10%
-37.7%
47
THCHFrequency Therapeutics, Inc.
COM
$21.99M
0.10%
-19.9%
48
Tricida, Inc.
COM
$21.64M
0.10%
-70.5%
49
NVAXNovavax, Inc.
COM
$20.12M
0.09%
New
50
BMRNBioMarin Pharmaceutical Inc.
NOTE 0.599% 8/1/2024
$18.34M
0.08%
-
Showing 1-50 of 114

Position Changes

StockValueShares
THCHForma Therapeutics Holdings, Inc.
$92.98M2,000,000
ADCTADC Therapeutics SA
$78.99M1,687,500
ALTAltimmune, Inc.
$22.57M2,107,600
NVAXNovavax, Inc.
$20.12M241,376
VXRTVaxart, Inc.
$14.51M1,639,121
XENEXenon Pharmaceuticals Inc.
$10.02M799,102
BNRBurning Rock Biotech Limited
$6.75M250,000
TARAProtara Therapeutics, Inc.
$5.85M199,671
LEGNLegend Biotech Corporation
$5.75M135,000
Chiasma, Inc.
$5.09M946,701
KZRKezar Life Sciences, Inc.
$3.11M600,000
GMDAQGamida Cell Ltd.
$3.05M666,666
Oyster Point Pharma, Inc.
$2.06M71,428
REPLReplimune Group, Inc.
$128.00K5,141