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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $12.07B
Positions: 133
Period: 2015-12-31
Filed: 2016-02-16
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$12.07B

Positions

133

New

8

Increased

25

Decreased

6

Sold Out

41

BAKER BROS. ADVISORS LP Q4 2015 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $12.07B across 133 positions in their Q4 2015 SEC 13F filing (period ending 2015-12-31). Top holdings include INCY ($2.11B), SE ($1.67B), Alexion Pharmaceuticals, Inc. ($1.25B). The top 10 positions account for 75.8% of the portfolio. This quarter saw 8 new positions, 25 increases, 6 reductions, 41 complete exits. Notable new buys: Anacor Pharmaceuticals Inc. ($152.29M), ALKS ($19.86M), PPL ($17.74M). Notable exits: THCH, THCH, Alder Biopharmaceuticals Inc..

All Holdings

#StockValue↓WeightChange
1
INCYIncyte Corporation
COM
$2.11B
17.50%
+0.0%
2
SESeattle Genetics, Inc.
COM
$1.67B
13.87%
+3.5%
3
Alexion Pharmaceuticals, Inc.
COM
$1.25B
10.34%
-
4
ABBVAbbVie Inc.
COM
$851.49M
7.05%
-
5
ACADACADIA Pharmaceuticals Inc.
COM
$730.16M
6.05%
-
6
ATIIncyte Corporation
NOTE 1.25% 11/15/2020 144A
$596.53M
4.94%
-
7
ATIIncyte Corporation
NOTE 0.375% 11/15/2018 144A
$556.69M
4.61%
-
8
THCHGenomic Health, Inc.
COM
$480.81M
3.98%
+0.0%
9
Anacor Pharmaceuticals, Inc.
COM
$474.31M
3.93%
+1.5%
10
BMRNBioMarin Pharmaceutical Inc.
COM
$431.10M
3.57%
+1.0%
11
Dyax Corp.
COM
$312.62M
2.59%
+9.9%
12
DBV Technologies S.A.
SPONSORED ADR
$198.33M
1.64%
-
13
THCHAcorda Therapeutics, Inc.
COM
$153.16M
1.27%
+226.4%
14
Anacor Pharmaceuticals Inc.
NOTE 2.0% 10/15/2021
$152.29M
1.26%
New
15
BCRXBioCryst Pharmaceuticals, Inc.
COM
$146.73M
1.22%
+0.8%
16
BMRNBioMarin Pharmaceutical Inc.
NOTE 1.875% 4/23/2017
$115.16M
0.95%
-
17
OLOClovis Oncology Inc.
NOTE 2.5% 9/15/2021
$110.98M
0.92%
-
18
Bellicum Pharmaceuticals, Inc.
COM
$98.63M
0.82%
+16.1%
19
Gilead Sciences Inc.
NOTE 1.625% 5/1/2016
$93.47M
0.77%
-
20
ATIMirati Therapeutics, Inc.
COM
$93.38M
0.77%
-
21
CERSCerus Corporation
COM
$85.66M
0.71%
-
22
Aquinox Pharmaceuticals, Inc.
COM
$84.21M
0.70%
-
23
HRTXHeron Therapeutics, Inc.
COM
$77.64M
0.64%
-
24
ImmunoGen, Inc.
COM
$60.42M
0.50%
+25.5%
25
THCHAcorda Therapeutics, Inc.
NOTE 1.75% 6/15/2021
$59.30M
0.49%
-13.4%
26
PARSpark Therapeutics, Inc.
COM
$57.20M
0.47%
-
27
Invitae Corporation
COM
$53.82M
0.45%
-
28
NBIXNeurocrine Biosciences, Inc.
COM
$48.13M
0.40%
+13.3%
29
Versartis, Inc.
COM
$40.17M
0.33%
-
30
SGMOSangamo BioSciences, Inc.
COM
$37.03M
0.31%
+8.0%
31
HALOHalozyme Therapeutics, Inc.
COM
$33.47M
0.28%
-
32
APGIntra-Cellular Therapies, Inc.
COM
$32.77M
0.27%
-
33
ATIMedivation, Inc.
COM
$31.89M
0.26%
-
34
PRGProgenics Pharmaceuticals, Inc.
COM
$26.67M
0.22%
-
35
GILDGilead Sciences, Inc.
COM
$25.30M
0.21%
-
36
TGTXTG Therapeutics, Inc.
COM
$23.91M
0.20%
-
37
Exelixis, Inc.
NOTE 4.25% 8/15/2019
$23.26M
0.19%
-
38
GLPGGalapagos NV
SPON ADR
$23.22M
0.19%
-
39
ATYRaTyr Pharma Inc.
COM
$22.95M
0.19%
-
40
Achillion Pharmaceuticals, Inc.
COM
$21.58M
0.18%
-
41
Idera Pharmaceuticals, Inc.
COM NEW
$21.58M
0.18%
+0.1%
42
CPRXCatalyst Pharmaceuticals, Inc.
COM
$20.27M
0.17%
+12.8%
43
ALKSAlkermes PLC
SHS
$19.86M
0.16%
New
44
XenoPort, Inc.
COM
$19.08M
0.16%
-46.6%
45
NVAXNovavax, Inc.
COM
$18.42M
0.15%
-
46
ARRYArray BioPharma Inc.
COM
$18.19M
0.15%
-
47
INSMInsmed, Inc.
COM PAR $.01
$18.15M
0.15%
-36.8%
48
PPLAdvanced Accelerator Applications SA
SPONSORED ADS
$17.74M
0.15%
New
49
Aegerion Pharmaceuticals, Inc.
NOTE 2.0% 8/15/2019
$17.55M
0.15%
-
50
Derma Sciences, Inc.
COM PAR $.01
$17.15M
0.14%
+8.5%
Showing 1-50 of 133

Position Changes

StockValueShares
Anacor Pharmaceuticals Inc.
$152.29M42,000,000
ALKSAlkermes PLC
$19.86M250,251
PPLAdvanced Accelerator Applications SA
$17.74M567,454
THCHDimension Therapeutics, Inc.
$13.93M1,234,481
NODKMedgenics Inc.
$4.61M765,000
Corsicanto Ltd.
$4.48M5,000,000
IONSIonis Pharmaceuticals, Inc.
$3.54M57,140
FLEXFlexion Therapeutics, Inc.
$2.83M146,642