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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $9.54B
Positions: 135
Period: 2016-06-30
Filed: 2016-08-15
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$9.54B

Positions

135

New

9

Increased

15

Decreased

16

Sold Out

56

BAKER BROS. ADVISORS LP Q2 2016 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $9.54B across 135 positions in their Q2 2016 SEC 13F filing (period ending 2016-06-30). Top holdings include INCY ($1.88B), SE ($1.75B), ABBV ($889.87M). The top 10 positions account for 82.7% of the portfolio. This quarter saw 9 new positions, 15 increases, 16 reductions, 56 complete exits. Notable new buys: NTLA ($22.68M), MRUS ($8.97M), NERV ($5.19M). Notable exits: Anacor Pharmaceuticals Inc. 2.0% 15 OCT 2021, Gilead Sciences, Inc. 1.625% 5/1/16, Anacor Pharmaceuticals, Inc..

All Holdings

#StockValue↓WeightChange
1
INCYIncyte Corporation
COM
$1.88B
19.70%
+0.0%
2
SESeattle Genetics, Inc.
COM
$1.75B
18.32%
+0.0%
3
ABBVAbbVie Inc.
COM
$889.87M
9.33%
-
4
ACADACADIA Pharmaceuticals Inc.
COM
$795.81M
8.34%
+1.3%
5
Alexion Pharmaceuticals, Inc.
COM
$764.00M
8.01%
+0.0%
6
ATIIncyte Corporation Notes 1.25% 11/15/2020 144A
NOTE 1.25% 11/15/2020
$467.29M
4.90%
-
7
ATIIncyte Corporation Notes 0.375% 11/15/2018 144A
NOTE 0.375% 11/15/2018
$431.83M
4.53%
-
8
BMRNBioMarin Pharmaceutical Inc.
COM
$373.94M
3.92%
-
9
THCHGenomic Health, Inc.
COM
$353.95M
3.71%
+0.1%
10
DBV Technologies S.A.
SPONSORED ADR
$179.72M
1.88%
-
11
XenoPort, Inc. Notes 2.5% 2/1/2022
NOTE 2.5% 2/1/2022
$98.47M
1.03%
-
12
THCHAcorda Therapeutics, Inc.
COM
$93.38M
0.98%
-
13
BMRNBioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017
NOTE 1.875% 4/23/2017
$84.91M
0.89%
-
14
CERSCerus Corporation
COM
$84.57M
0.89%
-
15
PARSpark Therapeutics, Inc.
COM
$67.41M
0.71%
+4.4%
16
THCHAcorda Therapeutics, Inc. Notes 1.75% 6/15/2021
NOTE 1.75% 6/15/2021
$67.35M
0.71%
-
17
Bellicum Pharmaceuticals, Inc.
COM
$63.06M
0.66%
-
18
ONCBeiGene, Ltd.
SPONSORED ADR
$57.00M
0.60%
-
19
HRTXHeron Therapeutics, Inc.
COM
$51.57M
0.54%
-1.7%
20
Aquinox Pharmaceuticals, Inc.
COM
$51.32M
0.54%
-
21
OLOClovis Oncology, Inc. 2.5% 9/15/2021
NOTE 2.5% 9/15/2021
$51.31M
0.54%
-43.7%
22
Invitae Corporation
COM
$48.44M
0.51%
-
23
BCRXBioCryst Pharmaceuticals, Inc.
COM
$42.63M
0.45%
-
24
NBIXNeurocrine Biosciences, Inc.
COM
$40.70M
0.43%
-
25
Versartis, Inc.
COM
$30.12M
0.32%
-14.9%
26
Exelixis, Inc. Notes 4.25% 8/15/2019
NOTE 4.25% 8/15/2019
$29.65M
0.31%
-
27
PPLAdvanced Accelerator Applications S.A.
SPONSORED ADR
$25.19M
0.26%
+35.5%
28
XenoPort, Inc.
COM
$24.47M
0.26%
-
29
APGIntra-Cellular Therapies, Inc.
COM
$23.65M
0.25%
-
30
SGMOSangamo BioSciences, Inc.
COM
$23.48M
0.25%
-
31
NTLAIntellia Therapeutics, Inc.
COM
$22.68M
0.24%
New
32
EXELExelixis, Inc.
COM
$20.15M
0.21%
-
33
ATIMedivation, Inc.
COM
$19.89M
0.21%
-
34
Achillion Pharmaceuticals, Inc.
COM
$19.31M
0.20%
-
35
NVAXNovavax, Inc.
COM
$17.30M
0.18%
-
36
PRGProgenics Pharmaceuticals, Inc.
COM
$16.75M
0.18%
-8.7%
37
XNCRXencor, Inc.
COM
$16.56M
0.17%
-
38
HALOHalozyme Therapeutics, Inc.
COM
$15.86M
0.17%
-4.8%
39
ARRYArray BioPharma Inc.
COM
$15.35M
0.16%
-
40
Corsicanto Ltd. 3.5% 1/15/2032
NOTE 3.5% 1/15/2032
$15.29M
0.16%
-
41
Aegerion Pharmaceuticals, Inc. Notes 2.0% 8/15/2019
NOTE 2.0% 8/15/2019
$14.84M
0.16%
-
42
INSMInsmed Incorporated
COM PAR $.01
$14.79M
0.16%
-
43
Derma Sciences, Inc.
COM PAR $.01
$14.78M
0.16%
-
44
GLPGGalapagos NV
SPONSORED ADR
$14.42M
0.15%
-14.3%
45
Foamix Pharmaceuticals Ltd.
SHS
$14.23M
0.15%
-
46
BMRNBioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018
NOTE 0.75% 10/15/2018
$13.57M
0.14%
-
47
BLUEbluebird bio, Inc.
COM
$12.72M
0.13%
-16.7%
48
ATIMirati Therapeutics, Inc.
COM
$12.39M
0.13%
-30.6%
49
TGTXTG Therapeutics, Inc.
COM
$12.14M
0.13%
-
50
ALKSAlkermes plc
SHS
$10.82M
0.11%
-
Showing 1-50 of 135

Position Changes

StockValueShares
NTLAIntellia Therapeutics, Inc.
$22.68M1,062,120
MRUSMerus N.V.
$8.97M1,122,859
NERVMinerva Neurosciences, Inc.
$5.19M508,405
SYRSSyros Pharmaceuticals, Inc.
$3.71M204,465
GLYCGlycoMimetics, Inc.
$2.77M381,235
Selecta Biosciences, Inc.
$2.50M178,950
THCHAeglea BioTherapeutics, Inc.
$1.97M404,230
SCYXSCYNEXIS, Inc.
$1.01M467,600
WINTWindtree Therapeutics, Inc.
$492.00K254,973