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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $10.20B
Positions: 133
Period: 2016-12-31
Filed: 2017-02-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$10.20B

Positions

133

New

7

Increased

14

Decreased

19

Sold Out

73

BAKER BROS. ADVISORS LP Q4 2016 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $10.20B across 133 positions in their Q4 2016 SEC 13F filing (period ending 2016-12-31). Top holdings include SE ($2.41B), INCY ($2.36B), Alexion Pharmaceuticals, Inc. ($800.57M). The top 10 positions account for 83.9% of the portfolio. This quarter saw 7 new positions, 14 increases, 19 reductions, 73 complete exits. Notable new buys: AveXis, Inc. ($15.05M), BIIB ($4.68M), MEDG ($4.56M). Notable exits: OLO, THCH, TGTX.

All Holdings

#StockValue↓WeightChange
1
SESeattle Genetics, Inc.
COM
$2.41B
23.65%
+3.7%
2
INCYIncyte Corporation
COM
$2.36B
23.10%
+0.0%
3
Alexion Pharmaceuticals, Inc.
COM
$800.57M
7.85%
-
4
ACADACADIA Pharmaceuticals Inc.
COM
$744.64M
7.30%
-
5
ATIIncyte Corporation
NOTE 1.25% 11/15/2020
$558.65M
5.48%
-
6
ATIIncyte Corporation
NOTE 0.375% 11/15/2018
$518.14M
5.08%
-
7
THCHGenomic Health, Inc.
COM
$404.71M
3.97%
-
8
BMRNBioMarin Pharmaceutical Inc.
COM
$398.17M
3.90%
-
9
DBV Technologies S.A.
SPONSORED ADR
$193.55M
1.90%
-
10
Aquinox Pharmaceuticals, Inc.
COM
$173.95M
1.71%
-
11
ONCBeiGene, Ltd.
SPONSORED ADR
$111.52M
1.09%
+92.0%
12
ABBVAbbVie Inc.
COM
$105.58M
1.03%
-88.2%
13
BMRNBioMarin Pharmaceutical Inc.
NOTE 1.875% 4/23/2017
$90.53M
0.89%
-
14
BCRXBioCryst Pharmaceuticals, Inc.
COM
$69.40M
0.68%
-
15
AMRNAmarin Corporation plc
SPONSORED ADR NEW
$68.28M
0.67%
+7.5%
16
Bellicum Pharmaceuticals, Inc.
COM
$66.27M
0.65%
-
17
PARSpark Therapeutics, Inc.
COM
$65.78M
0.64%
-
18
THCHAcorda Therapeutics, Inc.
COM
$62.07M
0.61%
-9.8%
19
Achaogen, Inc.
COM
$59.66M
0.58%
+4482.4%
20
PPLAdvanced Accelerator Applications S.A.
SPONSORED ADR
$57.99M
0.57%
+110.6%
21
Invitae Corporation
COM
$57.87M
0.57%
+11.2%
22
CERSCerus Corporation
COM
$56.78M
0.56%
-
23
EXELExelixis, Inc.
COM
$44.78M
0.44%
-39.1%
24
NBIXNeurocrine Biosciences, Inc.
COM
$34.65M
0.34%
-
25
HRTXHeron Therapeutics, Inc.
COM
$31.23M
0.31%
-16.6%
26
Versartis, Inc.
COM
$28.62M
0.28%
-10.0%
27
Foamix Pharmaceuticals Ltd.
SHS
$27.38M
0.27%
-
28
PRGProgenics Pharmaceuticals, Inc.
COM
$27.22M
0.27%
-13.7%
29
THCHAcorda Therapeutics, Inc.
NOTE 1.75% 6/15/2021
$26.57M
0.26%
-54.5%
30
MRUSMerus N.V.
COM
$24.49M
0.24%
-
31
XNCRXencor, Inc.
COM
$22.95M
0.23%
-
32
ARRYArray BioPharma Inc.
COM
$22.73M
0.22%
-21.9%
33
BLUEbluebird bio, Inc.
COM
$21.68M
0.21%
+19.6%
34
ASNDAscendis Pharma A/S
SPONSORED ADR
$20.71M
0.20%
+37.3%
35
Derma Sciences, Inc.
COM PAR $.01
$19.51M
0.19%
-
36
Aegerion Pharmaceuticals, Inc.
NOTE 2.0% 8/15/2019
$19.10M
0.19%
-
37
GLPGGalapagos NV
SPONSORED ADR
$16.68M
0.16%
-
38
Idera Pharmaceuticals, Inc.
COM NEW
$15.41M
0.15%
+46.5%
39
AveXis, Inc.
COM
$15.05M
0.15%
New
40
NTLAIntellia Therapeutics, Inc.
COM
$13.92M
0.14%
-
41
THCHAimmune Therapeutics, Inc.
COM
$13.78M
0.14%
-
42
HALOHalozyme Therapeutics, Inc.
COM
$13.75M
0.13%
-19.6%
43
BMRNBioMarin Pharmaceutical Inc.
NOTE 0.75% 10/15/2018
$13.73M
0.13%
-
44
NeuroDerm Ltd.
ORD SHS
$12.69M
0.12%
+87.4%
45
SGMOSangamo Therapeutics, Inc.
COM
$12.37M
0.12%
-
46
AERIEURAerie Pharmaceuticals, Inc.
COM
$11.33M
0.11%
-
47
ATIMirati Therapeutics, Inc.
COM
$10.78M
0.11%
-
48
SAGESage Therapeutics, Inc.
COM
$10.64M
0.10%
-
49
NODKZogenix, Inc.
COM NEW
$10.19M
0.10%
-16.1%
50
Dermira, Inc.
COM
$9.90M
0.10%
-
Showing 1-50 of 133

Position Changes

StockValueShares
AveXis, Inc.
$15.05M315,300
BIIBBiogen Inc.
$4.68M16,500
MEDGAevi Genomic Medicine, Inc.
$4.56M880,539
MIRARa Pharmaceuticals, Inc.
$2.70M177,952
CRBPCorbus Pharmaceuticals Holdings, Inc.
$2.20M260,129
BKTISpring Bank Pharmaceuticals, Inc.
$1.75M219,298
THCHCymaBay Therapeutics, Inc.
$535.00K309,268